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GENDIA & Pharmacogenetics
GENDIA
P
harmacogenetics
A: Choosing the Right Medication: Drug Specificity
1. BCR-ABL and Gleevec
2. HER2/NEU and Herceptin
3. EGFR and Iressa
4. KIT and Gleevec
5. PDGFRA and Gleevec
6. PDGFB and Gleevec
7. FLT3
B: Choosing the Right Dose: Drug Efficacity and Toxicity
1:
Phase I Enzymes
2:
Phase II Enzymes
3:
Genetic Variation in Activity of Phase I and Phase II Enzymes
4:
Examples
Cytochrome P450
CYP2D6
CYP2C9
CYP2C19
TPMT and Thiopurine toxicity
DPD and 5-Fluoro Uracil toxicity
UGT1A1 and Irinotecan toxicity
NAT-2 and Isoniazid toxicity
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